Chrono-log offers a complete line of highly concentrated platelet aggregation reagents. Because of the high concentrations of Chrono-log reagents, only micro-portions of reagent are used per test, resulting in high accuracy and extremely low cost per test. The standard aggregation reagents thrombin, ADP, collagen, ristocetin, epinephrine and arachidonic acid are available as well as CHRONO-LUME® reagent for determination of dense granule release when used in the Chrono-log Lumi-Aggregometer.

No. 384 ADP - each vial contains 2.5 mg of lyophilized adenosine diphosphate. Performs 500 to 1,000 tests.

No. 385 Collagen - each vial contains 1 mg of native collagen fibrils (type I) from equine tendons suspended in isotonic glucose solution of pH 2.7. Performs 500 to 1,000 tests.

No. 386 Thrombin - each vial contains a minimum of 10 units of lyophilized thrombin from human plasma. Performs 10 to 20 tests.

No. 390 Arachidonic Acid - each vial contains a minimum of 10 mg of arachidonic acid, purity better than 99%. Included is a vial containing 100 mg bovine albumin, fraction V powder, 96% to 99% purity. Performs 70 to 140 tests.

No. 396 Ristocetin - each vial contains 62.5 mg of stabilized freeze dried ristocetin. Performs 62 to 125 tests.

No. 393 Epinephrine - lyophilized preparation of 1-epinephrine bitartarate with stabilizers. Performs 1000 or more tests.

No. 395 CHRONO-LUME® reagent for measurement of ATP release. Each vial contains 0.2 mg luciferin, 22,000 units d-luciferase plus magnesium sulphate, human serum albumin, stabilizers and buffer. Kit includes 4 vials of CHRONO- LUME plus a vial of lyophilized adenosine 5' triphosphate for use as an ATP standard. Performs 50 to 100 tests.

A recent year long study evaluated the exceptional stability of Chrono-log aggregation reagents.

Chrono-log also provides a complete system to perform the ristocetin cofactor assay including the Reagent Kit, Software Package and Dual or Four- Channel Optical Aggregometers, priced to make diagnosis of Von WILLEBRAND's disease affordable.

The low cost, fifteen (15) test kit Ristocetin Cofactor Assay kit is usable with any Chrono-log Optical Aggregometer and can be used with or without the AGGRO/LINK® Cofactor Program. Each Kit contains Human Lyophilized Platelets, Tris Buffer Saline, Ristocetin, vWD Normal Reference Plasma and VWD Deficient Reference Plasma. All kit components are also available separately. The von Willebrand Co-factor Software Package provides for calculation of test results in percent of activity, calculation of standard curve for 2 to 6 points, monitoring of "Coefficient of Variation", reporting of "Coefficient of Determination" (R2), and storage of standard curves for future reference. On-Screen instructions for running the assay and the capability of running replicate tests insure efficient operation. The software is available for WINDOWS or DOS.

Chrono-log offers a complete line of reagents, aggregometers and supplies providing a single source for all your platelet aggregation needs. For further information, fill out and transmit our Electronic Reply Card or e-mail your request today. You can also call us at 1-800-CHRONOLOG (1-800-247-6665) or fax us at 610-853- 3972.